Pragmatic Trials

Our Approach

We implement pragmatic trials across multi-site networks, embedded within our Point32Health payer data, in partnership with large national health plans, or through leveraging systems and data from among our many other research partners.

Our capabilities include:

Use of real-world data for study operations: supporting recruitment, interventiondelivery, and analysis
Flexible randomization strategies: including individual- andcluster-level designs depending on feasibility‍
Integration with healthcare systems: embedding studies within routineworkflows
Multi-site and distributed implementation: nesting pragmatic trials withinestablished multi-site research networks to achieve scale and consistency ‍
Alignment with decision-making needs: ensuring designs are fit for regulatory,clinical, and policy contexts

What We Do

We use real-world data to support pragmatic trials through identification of patients, delivery of interventions, and assessment of outcomes including:

Efficient identification and recruitment of study populations: Using existing data sources to define and enroll eligible patients
Integration of interventions into routine care: Including the ability to support individual-, practice-, or payer-level implementation
Scalable follow-up for outcomes: Leveraging claims and EHR data for outcome capture without intensive primary data collection
Larger, more representative study populations: Supporting evaluation of real-world evidence across diverse settings

Highlighted Publications and Study Protocols

Effect of Mailing Educational Material to Patients With Atrial Fibrillation and Their Clinicians on Use of Oral Anticoagulants: A Randomized Clinical Trial

Authors: Pokorney SD, Cocoros N, Al-Khalidi HR, Haynes K, Li S, Al-Khatib SM, Corrigan-Curay J, Driscoll MR, Garcia C, Calvert SB, Harkins T, Jin R, Knecht D, Levenson M, Lin ND, Martin D, McCall D, McMahill-Walraven C, Nair V, Parlett L, Petrone A, Temple R, Zhang R, Zhou Y, Platt R, Granger CB

Published JAMA Network Open on May 2, 2022

Pragmatic Guidance for Embedding Pragmatic Clinical Trials in Health Plans: Large Simple Trials Aren't So Simple

Authors: Cocoros NM, Gurwitz JH, Cziraky MJ, Granger CB, Harkins T, Haynes K, Li X, Parlett L, Seeger JD, Singh S, McMahill-Walraven CN, Platt R

‍Published in Clinical Trials on June 15, 2023

Explore Publications

Explore our full publication library to learn more about the studies and methods that inform our work.
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publications