International Collaborations

Our Approach

Our leadership in building large-scale distributed data networks has contributed to the development of CNODES in Canada, and our researchers have collaborated with international partners across Europe to inform the design and operations of global real-world evidence networks.

We design international studies that account for differences in data, healthcare delivery, and regulatory expectations.

Our approach includes:

Transatlantic study design and coordination: aligning protocols across US and European partners
Experience with multiple regulatory environments: including studies relevant to both the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), and Health Canada
Collaboration with international data networks: working within established infrastructures to enable scalable, multi-country research
Harmonization of data and methods: ensuring consistency while accounting for regional differences
Distributed and multi-site implementation: applying scalable approaches across international partners

What We Do

We collaborate with international partners to designand conduct real-world evidence studies that span geographies by integrating data, methods, and scientific leadership across settings.

We support international real-world evidence studies across a range of applications, including:

Post-approval safety and effectiveness studies
Comparative studies across healthcare systems
Studies of rare exposures and outcomes
Regulatory-focused studies requiring multi-region evidence

What Does Transatlantic Collaboration Enable?

Generating evidence across regions can be essential when questions extend beyond the scope of any single data source or healthcare system.

Increased study scale and statistical power: particularly for rare exposures and outcomes
Evaluation across diverse healthcare systems: strengthening generalizability and interpretability‍
Alignment with multiple regulatory perspectives: supporting evidence generation relevant to both US and European decision-making
Complementary data sources: leveraging differences in data capture, coding, and clinical practice

International Collaborations

Our Approach

What We Do

What Does Transatlantic Collaboration Enable?

Explore Publications