International Collaborations

We collaborate with international partners to design and conduct real-world evidence studies that span geographies by integrating data, methods, and scientific leadership across settings.

Our leadership in building large-scale distributed data networks has contributed to the development of CNODES in Canada, and our researchers have collaborated with international partners across Europe to inform the design and operations of global real-world evidence networks.

Why International Collaboration Matters

In some cases, US-based data alone may be insufficient to answer key questions. Similarly, studies conducted in Europe or other regions may benefit from complementary US data.

What does transatlantic collaboration enable?

Increased study scale and statistical power: particularly for rare exposures and outcomes
Evaluation across diverse healthcare systems: strengthening generalizability and interpretability
‍Alignment with multiple regulatory perspectives: supporting evidence generation relevant to both US and European decision-making
Complementary data sources: leveraging differences in data capture, coding, and clinical practice

Generating evidence across regions can be essential when questions extend beyond the scope of any single data source or healthcare system

Our Approach

We design international studies that account for differences in data, healthcare delivery, and regulatory expectations.

Our approach includes:

Transatlantic study design and coordination: aligning protocols across US and European partners

Experience with multiple regulatory environments: including studies relevant to both the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), and Health Canada

Collaboration with international data networks: working within established infrastructures to enable scalable, multi-country research

Harmonization of data and methods: ensuring consistency while accounting for regional differences

Distributed and multi-site implementation: applying scalable approaches across international partners

What We Do

We support international real-world evidence studies across a range of applications, including:

Post-approval safety and effectiveness studies
Comparative studies across healthcare systems
Studies of rare exposures and outcomes
Regulatory-focused studies requiring multi-region evidence